the antioxidant effect of erythropoietin on thalassemic blood

the antioxidant effect of erythropoietin on thalassemic blood

The antioxidant effect of erythropoietin on thalassemic blood

The antioxidant effect of erythropoietin on thalassemic blood cells. Anemia. 2010;2010:978710. doi: 10.1155/2010/978710. Epub 2010 Dec 21.

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the antioxidant effect of erythropoietin on thalassemic blood

The Antioxidant Effect of Erythropoietin on Thalassemic Blood

The Antioxidant Effect of Erythropoietin on Thalassemic Blood Cells. Johnny Amer,1 Mutaz Dana,1 and Eitan Fibach 1. 1Department of Hematology, Hadassah-Hebrew University Medical Center, Ein-Kerem, 91120 Jerusalem, Israel. Academic Editor: Aurelio Maggio.

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the antioxidant effect of erythropoietin on thalassemic blood

The antioxidant effect of erythropoietin on thalassemic blood

The effects were observed in vitro by incubating peripheral blood RBC with Epo as well as shortly (3 hrs) after injection of Epo into β-thalassemic mice. These results are in agreement with reports by Datta et al. who showed that Epo has multiple effects on mature RBC, including an anti-oxidative one [ 37 , 67 – 72 ].

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the antioxidant effect of erythropoietin on thalassemic blood

The Antioxidant Effect of Erythropoietin on Thalassemic Blood

Effect of Epo on the oxidative stress of RBC and platelets from thalassemic patients. Diluted blood samples were untreated with or without 1 U/ml Epo for 3 hrs at 37°C, then stimulated (a, b) or

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the antioxidant effect of erythropoietin on thalassemic blood

The Antioxidant Effect of Erythropoietin on Thalassemic Blood

Flow cytometry analysis of the Epo effect on ROS generation by RBC and platelets. A diluted blood sample obtained from a thalassemia patient was treated for 2 hrs with Epo (1 U/ml) at 37°C, stained with DCF and then stimulated with 1 mM H 2 O 2 for 15 min. (a) FCS versus SSC dot plot. The gates indicate the position of platelets (R1) and RBC (R2).

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the in vitro and in vivo antioxidant effects of

The In Vitro and In Vivo Antioxidant Effects of

Erythropoietin (EPO), a hormone produced on hypoxia mainly in the kidneys, enhances red blood cell (RBC) production (erythropoiesis) by stimulating the proliferation of erythroid progenitors and precursors in the bone marrow. This effect is mediated by the homodimeric EPO receptor, a class 1 cytokine receptor.

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theantioxidanteffectoferythropoietinonthalassemic bloodcells

TheAntioxidantEffectofErythropoietinonThalassemic BloodCells

Erythropoietin (Epo), a hormone released upon hypoxia mainly in the kidneys, enhances red blood cell (RBC) production (erythropoiesis) by stimulating the proliferation

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the antioxidant effect of erythropoietin on thalassemic blood

The Antioxidant Effect of Erythropoietin on Thalassemic Blood

Because of its stimulating effect on RBC production, erythropoietin (Epo) is used to treat anemia, for example, in patients on dialysis or on chemotherapy. In β-thalassemia, where Epo levels are low relative to the degree of anemia, Epo treatment improves the anemia state.

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the antioxidant effect of erythropoietin on thalassemic blood

The Antioxidant Effect of Erythropoietin on Thalassemic Blood

Flow cytometry analysis of the Epo effect on ROS generation by RBC and platelets. A diluted blood sample obtained from a thalassemia patient was treated for 2 hrs with Epo (1 U/ml) at 37°C, stained with DCF and then stimulated with 1 mM H 2 O 2 for 15 min. (a) FCS versus SSC dot plot.

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doi:10.1155/2010/978710 research article the antioxidant

doi:10.1155/2010/978710 Research Article The Antioxidant

research article antioxidant effect reduced susceptibility original work membrane lipid peroxide external phosphatidylserine hbb th3 glutathione content creative common attribution license thalassemic mouse reactive oxygen specie anemia state epo treatment fetal hemoglobin production flow-cytometry technology unrestricted use blood cell epo

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the antioxidant effect of erythropoietin on thalassemic blood

The Antioxidant Effect of Erythropoietin on Thalassemic Blood

The Antioxidant Effect of Erythropoietin on Thalassemic Blood

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1. introduction

1. Introduction

ANE Anemia 2090-1275 2090-1267 Hindawi Publishing Corporation 978710 10.1155/2010/978710 978710 Research Article The Antioxidant Effect of Erythropoietin on Thalassemic Blood Cells Amer Johnny Dana Mutaz Fibach Eitan Maggio Aurelio Department of Hematology Hadassah-Hebrew University Medical Center Ein-Kerem, 91120 Jerusalem Israel huji.ac.il

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“effects of recombinant human erythropoietin high mimicking

“Effects of recombinant human erythropoietin high mimicking

In recent years many studies have focused their interest on the possible effects of erythropoietin on the oxidative stress related processes showing conflicting results. rHuEPO was reported to reduce oxidative stress damage in heart disease to provide cardio-protection, have antioxidant effect in thalassemic blood cells and reduce ROS

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correcting β-thalassemia by combined therapies that restrict

Correcting β-thalassemia by combined therapies that restrict

β-Thalassemia intermedia is a disorder characterized by ineffective erythropoiesis (IE), anemia, splenomegaly, and systemic iron overload. Novel approaches are being explored based on the modulation of pathways that reduce iron absorption (ie, using hepcidin activators like Tmprss6-antisense oligonucleotides [ASOs]) or increase erythropoiesis (by erythropoietin [EPO] administration or

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correlation between erythropoietin serum levels and

Correlation between erythropoietin serum levels and

Amer J, Dana M, Fibach E: The antioxidant effect of erythropoietin on thalassemic blood cells. Anemia 2010 , ID 978710 ( 2010 ) Amer J , Dana M , Fibach E : The antioxidant effect of erythropoietin on thalassemic blood cells .

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the effect of erythropoietin on the cellular defence

The effect of erythropoietin on the cellular defence

The glutathione redox system, haemoglobin (Hb) oxidation, the activity of antioxidant enzymes and the lipid peroxidation product malonyl dialdehyde (MDA) were studied in red blood cells (RBCs) during administration of recombinant human erythropoietin (rhEPO) over 12 weeks in ten children maintained on haemodialysis. A rapid increase in the reticulocyte count was accompanied by a slower rise in

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antioxidant effect of erythropoietin during experimental

Antioxidant Effect of Erythropoietin during Experimental

Antioxidant Effect of Erythropoietin during Experimental Chronic Renal Failure. Osikov MV(1), Telesheva LF(2), Ageev YI(2). Author information: (1)South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia. [email protected] (2)South Ural State Medical University, Ministry of Health of the Russian

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ampk is involved in mediation of erythropoietin influence on

AMPK is involved in mediation of erythropoietin influence on

EPO also has antioxidant effect in thalassemic blood cells (Amer et al., 2010). In this study, EPO was found to inhibit ROS production in adipocytes and the adipocyte and WAT expression of antioxidant enzymes were also increased by EPO. Insulin resistance has been associated with the generation of ROS.

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effect of erythropoietin therapy and selenium supplementation

Effect of erythropoietin therapy and selenium supplementation

Effect of erythropoietin therapy and selenium supplementation on selected antioxidant parameters in blood of uremic patients on long-term hemodialysis. Adamowicz A(1), Trafikowska U, Trafikowska A, Zachara B, Manitius J. Author information: (1)Department of Nephrology, Medical University, Bydgoszcz, Poland.

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“effects of recombinant human erythropoietin high mimicking

“Effects of recombinant human erythropoietin high mimicking

In recent years many studies have focused their interest on the possible effects of erythropoietin on the oxidative stress related processes showing conflicting results. rHuEPO was reported to reduce oxidative stress damage in heart disease to provide cardio-protection, have antioxidant effect in thalassemic blood cells and reduce ROS

Contact Suppliers
correlation between erythropoietin serum levels and

Correlation between erythropoietin serum levels and

Amer J, Dana M, Fibach E: The antioxidant effect of erythropoietin on thalassemic blood cells. Anemia 2010 , ID 978710 ( 2010 ) Amer J , Dana M , Fibach E : The antioxidant effect of erythropoietin on thalassemic blood cells .

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editor’s pick: new insights in β-thalassaemia - european

Editor’s Pick: New Insights in β-Thalassaemia - European

Rachmilewitz EA et al. Sustained increase in haemoglobin and RBC following long-term administration of recombinant human erythropoietin to patients with homozygous beta-thalassaemia. Br J Haematol. 1995;90(2):341-5. Amer J et al. The antioxidant effect of erythropoietin on thalassemic blood cells. Anemia. 2010;2010:978710. Dussiot M et al.

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does erythropoietin have a role in the treatment of β

Does Erythropoietin Have a Role in the Treatment of β

Erythropoietin (Epo), a hormone released in response to hypoxia mainly in the kidneys, is the major regulator of red blood cell (RBC) production (erythropoiesis). By binding to a surface receptor, it stimulates proliferation and inhibits apoptosis of erythroid progenitors and precursors in the bone marrow.

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purification of human blood burst‐forming units‐erythroid and

Purification of human blood burst‐forming units‐erythroid and

Jacqueline E. Damen, Jana Krosl, Donna Morrison, Steven Pelech, Gerald Krystal, The Hyperresponsiveness of Cells Expressing Truncated Erythropoietin Receptors Is Contingent on Insulin-Like Growth Factor-1 in Fetal Calf Serum, Blood, 10.1182/blood.V92.2.425.414k08_425_433, 92, 2, (425-433), (1998).

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