studies on dibutyl phthalate-induced testicular atrophy

studies on dibutyl phthalate-induced testicular atrophy in

Studies on dibutyl phthalate-induced testicular atrophy in

PHTHALATE-INDUCED TESTICULAR ATROPHY 613 In further studies it was found that comparable losses in testicular weight were obtained at lower dose levels over an extended period of treatment (Table 2). The DBP dose of 2000 mg/kg was chosen for subsequent studies to optimize conditions leading to the development of testicular lesions.

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studies on dibutyl phthalate-induced testicular atrophy in

Studies on dibutyl phthalate-induced testicular atrophy in

The daily oral administration of dibutyl phthalate (DBP) at 2000 mg/kg for 4 days to young male rats was found to produce testicular injury and loss in organ weight. Additionally, it was found that DBP treatment adversely affected zinc metabolism. The urinary excretion of zinc was increased and the zinc content in the testes was markedly decreased.

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studies on dibutyl phthalate-induced testicular atrophy in

Studies on dibutyl phthalate-induced testicular atrophy in

The daily oral administration of dibutyl phthalate (DBP) at 2000 mg/kg for 4 days to young male rats was found to produce testicular injury and loss in organ weight. Additionally, it was found that DBP treatment adversely affected zinc metabolism. The urinary excretion of zinc was increased and the zinc content in the testes was markedly decreased. Moreover; the turnover rate of this element

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studies on dibutyl phthalate-induced testicular atrophy in

Studies on dibutyl phthalate-induced testicular atrophy in

Studies on dibutyl phthalate-induced testicular atrophy in the rat: effect on zinc metabolism.

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mechanism of testicular atrophy induced by di-n-butyl

Mechanism of testicular atrophy induced by Di-n-butyl

In previous studies we have described mechanisms of testicular atrophy whereby di-n-butyl phthalate (DBP) caused a sloughing of the germ cells, prior to the testicular atrophy; this sloughing might be attributed to iron depletion in the blood and the testicular interstitial cells.

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mechanism of testicular atrophy induced by di-n-butyl

Mechanism of testicular atrophy induced by di-n-butyl

In vitro studies where mono-n-butyl phthalate (MBP) was incubated with liver homogenates, MBP caused both the decreases in Hb and Tf-bound iron levels and increases in Hs and Hs-iron levels. The present study proposes that the mechanism of testicular atrophy by DBP might be associated with both the iron release from Hb and/or Tf in the liver

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studies on dibutyl phthalate-induced testicular atrophy - new

studies on dibutyl phthalate-induced testicular atrophy - New

PHTHALATE-INDUCED TESTICULAR ATROPHY 611 the chloride salt in saline solution, was injected 48 hr prior to the commencement of DBP treatment. In studies on the

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mechanism of testicular atrophy induced by di‐n‐butyl

Mechanism of testicular atrophy induced by Di‐n‐butyl

Repeated oral doses of di‐n‐butyl phthalate (DBP) to male rats caused a decrease in testicular fructose and glucose and a sloughing of the germ cells on the first day of treatment. On day 2, more severe sloughing was seen and was accompanied by decreases in testicular iron and zinc levels and increases in the level of inositol and cholesterols. The sloughing was followed by atrophy

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mechanism of testicular atrophy induced by di-n-butyl

Mechanism of testicular atrophy induced by di-n-butyl

Mechanism of testicular atrophy induced by di-n-butyl phthalate in rats. Part 4. Changes in the activity of succinate dehydrogenase and the levels of transferrin and ferritin in the Sertoli and germ cells

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di-n-butyl phthalate (dbp) exposure induces oxidative stress

Di-n-butyl phthalate (DBP) exposure induces oxidative stress

Di-n-butyl phthalate (DBP) is a ubiquitous environmental pollutant, extensively used as a plasticizer in many products including plastics, cosmetics and medical devices. Previous studies have shown that DBP has potential testicular toxicity. Epididymis is known to play an important role in the maturation and storage of sperm.

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mechanism of testicular atrophy induced by di‐n‐butyl

Mechanism of testicular atrophy induced by Di‐n‐butyl

Din-butyl phthalate (DBP) was chosen for this study since the period for appearance of the testicular atrophy by DBP was longer than by di-n-pentyl phthalate (DPP) and shorter than by DEHP.8.9.12 This study was aimed at investigating mechanisms of DBP-induced testicular atrophy from histological and biochemical perspectives.

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curcumin and kolaviron ameliorate di‐n‐butylphthalate‐induced

Curcumin and Kolaviron Ameliorate Di‐n‐Butylphthalate‐Induced

Phthalate esters have been implicated in the decline of human sperm counts [] and testicular atrophy in an animal model [].The exact mechanisms involved in the formation of phthalate‐induced testicular atrophy are not known, but recently it was shown that administration of antioxidant vitamins together with di‐ethyl‐hexylphthalate prevented phthalate ester‐induced testicular atrophy in

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(pdf) toxicopathological studies of di butyl phthalate in

(PDF) TOXICOPATHOLOGICAL STUDIES OF DI BUTYL PHTHALATE IN

T oxicity studies of dibutyl phthalate (CAS no. 84-74-2) administered in. Studies on dibutyl phthalate-induced testicular atrophy in the rat: Effect on zinc metabolism. Article.

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prophylactic effects of vitamin e and selenium on di (n-butyl

Prophylactic effects of vitamin E and selenium on di (n-butyl

Phthalates including di(n butyl) phthalate (DBP) have been shown to induce testicular atrophy due to depletion of spermatogenic cells via apoptosis in rodents [3-8]. Increased oxidative damage of protein, lipid and DNA is one of the underlying mechanisms of DBP-induced testicular toxicity [9].

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effects of dibutyl phthalate in male rabbits following in

Effects of Dibutyl Phthalate in Male Rabbits following in

A majority of the studies using rats indicates testicular toxicity during this life stage is a Studies on dibutyl phthalate-induced testicular atrophy in the rat

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evidence of interaction between polychlorinated biphenyls and

Evidence of Interaction between Polychlorinated Biphenyls and

Studies on dibutyl phthalate-induced testicular atrophy in the rat: effect on zinc metabolism. Toxicol Appl Pharmacol 41:609-618 918990. Crossref, Medline, Google Scholar; CDC 2003. Second National Report on Human Exposure to Environmental Chemicals. Atlanta, GA:Centers for Disease Control and Prevention.

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mechanisms of testicular atrophy induced by di-n-butyl

Mechanisms of testicular atrophy induced by Di-n-butyl

Mechanisms of testicular atrophy induced by Di-n-butyl phthalate in rats. Part 3. Changes in the activity of some enzymes in the sertoli and germ cells, and in the levels of metal ions

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mechanism of testicular atrophy induced by di-n-butyl

Mechanism of testicular atrophy induced by di-n-butyl

Mechanism of testicular atrophy induced by di-n-butyl phthalate in rats. Part 4. Changes in the activity of succinate dehydrogenase and the levels of transferrin and ferritin in the Sertoli and germ cells

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curcumin and kolaviron ameliorate di‐n‐butylphthalate‐induced

Curcumin and Kolaviron Ameliorate Di‐n‐Butylphthalate‐Induced

Phthalate esters have been implicated in the decline of human sperm counts [] and testicular atrophy in an animal model [].The exact mechanisms involved in the formation of phthalate‐induced testicular atrophy are not known, but recently it was shown that administration of antioxidant vitamins together with di‐ethyl‐hexylphthalate prevented phthalate ester‐induced testicular atrophy in

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effects of dibutyl phthalate in male rabbits following in

Effects of Dibutyl Phthalate in Male Rabbits following in

A majority of the studies using rats indicates testicular toxicity during this life stage is a Studies on dibutyl phthalate-induced testicular atrophy in the rat

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evidence of interaction between polychlorinated biphenyls and

Evidence of Interaction between Polychlorinated Biphenyls and

Studies on dibutyl phthalate-induced testicular atrophy in the rat: effect on zinc metabolism. Toxicol Appl Pharmacol 41:609-618 918990. Crossref, Medline, Google Scholar; CDC 2003. Second National Report on Human Exposure to Environmental Chemicals. Atlanta, GA:Centers for Disease Control and Prevention.

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application of an mode of action framework to dibutyl

Application of an Mode of Action framework to Dibutyl

Applying the Key Characteristics Approach for Evaluation of Toxicological and Mechanistic Evidence on Benzo[a]Pyrene-Induced Male Reproductive Toxicity. Xabier Arzuaga PhD. U.S. EPA/ORD/CPAD. Wayne State University. School of Medicine, Pharmacology. Januaey 29, 2021

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testicular toxicity of di-(2-ethylhexyl)phthalate in young

Testicular toxicity of di-(2-ethylhexyl)phthalate in young

In this study, the protective effect of ginkgo biloba extract 761 (EGb 761)'s on testicular damage caused analyzed by giving the same dose di-(2-ethylhexyl) phthalate (DEHP) to rats at different

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[pdf] effects of di(2-ethylhexyl) phthalate on the gonadal

[PDF] Effects of di(2-ethylhexyl) phthalate on the gonadal

Dietary exposure of adult male F344 rats to 0, 320, 1250, 5000, or 20,000 ppm DEHP for 60 consecutive days resulted in a dose-dependent reduction in total body, testis, epididymis, and prostate weights at 5000 and 20,000 ppm. Degenerative changes were observed in testis, along with decreased testicular zinc content, reduced epididymal sperm density and motility, and increased occurrence of

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