pvc-plasticizer dehp in medical products: do thin coatings

pvc-plasticizer dehp in medical products: do thin coatings

PVC-plasticizer DEHP in medical products: do thin coatings

The hemocompatibility of artificial surfaces in extracorporeal blood circulation systems can be improved by coatings. According to the literature, heparin coatings should avoid the leaching of the plasticizer di(2-ethylhexyl) phthalate (DEHP) into the blood from components made from plasticized polyvinyl chloride (PVC).

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pvc-plasticizer dehp in medical products: do thin coatings

PVC-plasticizer DEHP in medical products: Do thin coatings

Request PDF | PVC-plasticizer DEHP in medical products: Do thin coatings really reduce DEHP leaching into blood? | The hemocompatibility of artificial surfaces in extracorporeal blood circulation

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effect of phospholipid coating on the migration of

Effect of phospholipid coating on the migration of

PVC-plasticizer DEHP in medical products: do thin coatings really reduce DEHP leaching into blood? Perfusion , 20 ( 2005 ) , pp. 351 - 357 CrossRef View Record in Scopus Google Scholar

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a new study on use of pvc based on dehp and alternate

A new study on use of PVC based on DEHP and alternate

DEHP [Di-(2-EthylHexyl) Phthalate] is the most widely used plasticizer in PVC medical devices for ensuring flexibility of parts required for a number of medical procedures. However, this plasticizer is increasingly coming under scanner of think-tanks and governmental bodies owing to its health and environmental concerns.

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prevention of plasticizer leaching from pvc medical devices

Prevention of plasticizer leaching from PVC medical devices

These hybrids were used as coatings for flexible PVC tubes in order to reduce the plasticizer leaching from PVC medical devices. Extraction tests carried out with hexane indicated that all coating composition investigated are able to strongly reduce (about one order of magnitude) the leaching of di-ethylhexyl phthalate in hexane.

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presence of plasticizer di-2(ethylhexyl)phthalate in primed

Presence of Plasticizer Di-2(ethylhexyl)phthalate in Primed

e (DEHP) from the polyvinyl chloride (PVC) tubing exist. The purpose of this study was to determine the time course of DEHP release from a preprimed ECMO circuit and to evaluate the effect of PVC tubing coatings on DEHP release. Seven circuits including three uncoated (Medtronic, Medtronic with albumin, and Medtronic Super Tygon) and four attenuated surfaces (Carmeda, COBE Smart, Medtronic

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controversy: neonatal exposure to plasticizers in the nicu

Controversy: neonatal exposure to plasticizers in the NICU

PVC-plasticizer DEHP in medical products: do thin coatings really reduce DEHP leaching into blood? Hildenbrand SL , Lehmann HD , Wodarz R , Ziemer G , Wendel HP Perfusion, (6):351-357 2005

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prevention of plasticizer leaching from pvc medical devices

Prevention of plasticizer leaching from PVC medical devices

Poly(vinyl chloride) (PVC) is a well-known commodity plastic widely used in coating, packaging, piping, clothing, and medical devices, because of its recognized merits including low cost, chemical

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plasma treatment decreases movement of plasticizers from

Plasma treatment decreases movement of plasticizers from

Medical products such as blood bags and tubing are often made from soft PVC, a plastic that contains phthalate plasticizers, which are suspected to be harmful to human health.

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a review of alternatives to di (2-ethylhexyl) phthalate

A review of alternatives to di (2-ethylhexyl) phthalate

Two alternative methods can replace DEHP in medical products. One method is to replace only the DEHP in PVC with a DEHP-free plasticizer to confer flexibility to a rigid polymer.

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5 things to know about getting dehp out of medical devices

5 things to know about getting DEHP out of medical devices

Phthalate esters such as diethylhexl-phthalate (DEHP) are the most widely used plasticizers for flexible poly-vinyl chloride (PVC) medical compounds and have been for 50 years, but issues concerning their possible effects on human health have caused some device manufacturers to consider compounds containing alternative plasticizers.

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latest medical plasticizers materials evolving to meet the

Latest Medical Plasticizers Materials Evolving to Meet the

Even though the health effects of DEHP have been questioned, it is still the plasticizer of choice for PVC medical and surgical products due to its plasticizing performance and cost. Because DEHP and other phthalate plasticizers used with PVC are not covalently bonded to the polymer, they may leach out in contact with certain media.

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sinodoschemistry - biocompatible coatings and coatings of

SinodosChemistry - Biocompatible coatings and coatings of

DEHP is the main reason for PVC based coatings being not considered suitable for some medical devices applications. DEHP leaks greatly under various physical, chemical and mechanical conditions and thus degrades PVC coatings acceptance by authorities and manufacturers. Alternatives to DEHP or other phthalates as plasticizers exist and many of

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dehp and bpa containing medical devices attestation form

DEHP and BPA containing medical devices attestation form

There are a couple issues with DEHP in medical products. First is that even if your product is made with, say, a TOTM plasticizer (a common one that we use in our PVC applications that is non-DEHP) is that unless your supplier is careful you run the risk of cross contamination.

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inflammatory response of rat and human neutrophils exposed to

Inflammatory Response of Rat and Human Neutrophils Exposed to

Sibylle L Hildenbrand, Hans-Dieter Lehmann, Roman Wodarz, Gerhard Ziemer, Hans P Wendel, PVC-plasticizer DEHP in medical products: do thin coatings really reduce DEHP leaching into blood?, Perfusion, 10.1191/0267659105pf836oa, 20, 6, (351-357), (2016).

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impact of non-di-(2-ethylhexyl)phthalate cardiopulmonary

Impact of non-di-(2-ethylhexyl)phthalate cardiopulmonary

Hildenbrand SL, Lehmann HD, Wodarz R, Ziemer G, Wendel HP. PVC-plasticizer DEHP in medical products: do thin coatings really reduce DEHP leaching into blood? Perfusion 2005;20:351–357. Article PubMed Google Scholar 9.

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opinion on medical devices containing dehp plasticised pvc

OPINION ON Medical Devices Containing DEHP Plasticised PVC

Virtually all medical devices made from PVC utilise one plasticizer, di (2-ethylhexyl) phthalate, also known as di-octyl phthalate, universally referred to as DEHP. It has been known for a long time that DEHP can leach out of PVC, resulting in exposure to body tissues and fluids. It has also been suspected that this DEHP has certain toxicity

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5 things to know about getting dehp out of medical devices

5 things to know about getting DEHP out of medical devices

Phthalate esters such as diethylhexl-phthalate (DEHP) are the most widely used plasticizers for flexible poly-vinyl chloride (PVC) medical compounds and have been for 50 years, but issues concerning their possible effects on human health have caused some device manufacturers to consider compounds containing alternative plasticizers.

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uses of phthalates and other plasticizers

Uses of Phthalates and Other Plasticizers

Plasticizers for Medical Products Subset Desired Plasticizer attributes Typical Products Not Preferred Invasive Use Prior approvals, long history of safe service, resists color change in sterilization, low color, low odor, high purity DEHP, trimellitates, citrates, polymerics C1-C7 phthalates, DINP, DIDP, DTDP, DPHP, linear phthalates

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suppliers going dehp-free, it’s easier than you think…

Suppliers going DEHP-free, it’s easier than you think…

SCENIHR Report: The Safety of Medical Devices containing DEHP-Plasticized PVC or Other Plasticizers Plasticizer Repeated dose toxicity, NOAEL, mg/kg bw/day (higher numbers are better) Genotoxicity Carcinogenicity Maternal toxicity, mg/kg bw/day DEHP 29 (male rat) Negative LOAEL 320 (male rat) LOAEL 750 (rat)

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presence of plasticizer di-2(ethylhexyl)phthalate in primed

Presence of Plasticizer Di-2(ethylhexyl)phthalate in Primed

Safety Division, Pharmaceutical and Food Safety Bureau, Notification No. 1017001 PVC-plasticizer DEHP in medical products: do thin coatings really reduce DEHP leaching into blood Nov 2002 351-357

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health risks posed by use of di‐2‐ethylhexyl phthalate (dehp

Health risks posed by use of Di‐2‐ethylhexyl phthalate (DEHP

Polyvinyl chloride plastics (PVC), made flexible through the addition of di‐2‐ethylhexyl phthalate (DEHP), are used in the production of a wide array of medical devices. From the late 1960s, leaching of DEHP from PVC medical devices and ultimate tissue deposition have been documented.

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thieme e-journals - seminars in thrombosis and hemostasis

Thieme E-Journals - Seminars in Thrombosis and Hemostasis

PVC-plasticizer DEHP in medical products: do thin coatings really reduce DEHP leaching into blood?. Perfusion 2005; 20 (06) 351-357 Perfusion 2005; 20 (06) 351-357 30 Haishima Y, Hayashi Y, Yagami T, Nakamura A. Elution of bisphenol-A from hemodialyzers consisting of polycarbonate and polysulfone resins .

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reducing the migration of pvc plasticizers

Reducing the migration of pvc plasticizers

ing medium. However, the plasticizers normally used, such as bis(2-ethylhexyl) phthalate (DEHP), are considered problematic for human health. For this reason, in current research at Fraunhofer IST processes are developed, which reduce or completely prevent the migration of plasticizers from the polymer, by coating or cross-linking the PVC.

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