prooxidant and antioxidant activities of bilirubin and its

prooxidant and antioxidant activities of bilirubin and its

Prooxidant and antioxidant activities of bilirubin and its

Thus bilirubin possesses both antioxidant and prooxidant properties. In order to understand the chemical basis of various biological properties of bilirubin, we have studied the structure-activity relationship between bilirubin and its precursor biliverdin. The latter has also been reported to possess both antioxidant and toxic properties.

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prooxidant and antioxidant activities of bilirubin and its

Prooxidant and antioxidant activities of bilirubin and its

Thus bilirubin possesses both antioxidant and prooxidant properties. In order to understand the chemical basis of various biological properties of bilirubin, we have studied the structure–activity relationship between bilirubin and its precursor biliverdin. The latter has also been reported to possess both antioxidant and toxic properties.

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10.1016/s0009-2797(01)00209-5 | deepdyve

10.1016/S0009-2797(01)00209-5 | DeepDyve

In order to understand the chemical basis of this reaction and to identify the mode of copper binding, in this paper we have compared the prooxidant and antioxidant properties of bilirubin with its structural analogue and precursor biliverdin. Based on these studies a model for Cu(II) binding of bilirubin has been proposed.

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pro-oxidant, anti-oxidant and cleavage activities on dna of

Pro-oxidant, anti-oxidant and cleavage activities on DNA of

Prooxidant and antioxidant activities of bilirubin and its metabolic precursor biliverdin: a structure-activity study. Asad SF, Singh S, Ahmad A, Khan NU, Hadi SM. Chem Biol Interact, 137(1):59-74, 01 Jul 2001 Cited by: 24 articles | PMID: 11518564

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the extent of intracellular accumulation of bilirubin

The Extent of Intracellular Accumulation of Bilirubin

In all the cell lines studied, iUCB of around 7 ng/mg protein had antioxidant activities, while iUCB > 25 ng/mg protein resulted in a prooxidant and cytotoxic effects. UCB metabolism was found to be cell-specific resulting in different iUCB.

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the extent of intracellular accumulation of bilirubin

The Extent of Intracellular Accumulation of Bilirubin

Among extensive series of antioxidants, bilirubin has the most potent superoxide and peroxide radical scavenger activities [20]. The potent physiologic antioxidant actions of bilirubin are further amplified by the oxidation of bilirubin to biliverdin and then recycled by biliverdin reductase back to bilirubin [18].

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the comparison of pro-oxidant-antioxidant balance in

The Comparison of Pro-Oxidant-Antioxidant Balance in

Jaundice can be observed in two-thirds of infants. Bilirubin prevents damage to the DNA from the oxidative stress of reactive oxygen species (ROS). Moreover, bilirubin has anti-inflammatory and anti-apoptotic roles in addition to antioxidant properties.We decided to compare pro-oxidant-antioxidant balance (PAB) in physiologic and pathologic jaundice.This cross-sectional study evaluated 171

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(pdf) the extent of intracellular accumulation of bilirubin

(PDF) The Extent of Intracellular Accumulation of Bilirubin

PDF | Background: Severe hyperbilirubinemia can cause permanent neurological damage in particular in neonates, whereas mildly elevated serum bilirubin | Find, read and cite all the research you

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pro-oxidant, anti-oxidant and cleavage activities on dna of

Pro-oxidant, anti-oxidant and cleavage activities on DNA of

Prooxidant and antioxidant activities of bilirubin and its metabolic precursor biliverdin: a structure-activity study. Asad SF, Singh S, Ahmad A, Khan NU, Hadi SM. Chem Biol Interact, 137(1):59-74, 01 Jul 2001 Cited by: 24 articles | PMID: 11518564

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(pdf) the extent of intracellular accumulation of bilirubin

(PDF) The Extent of Intracellular Accumulation of Bilirubin

PDF | Background: Severe hyperbilirubinemia can cause permanent neurological damage in particular in neonates, whereas mildly elevated serum bilirubin | Find, read and cite all the research you

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effect of phototherapy on pro-oxidant/antioxidant balance in

Effect of phototherapy on pro-oxidant/antioxidant balance in

is a unit stimulating the production of oxygen and acting as an antioxidant, especially when combined with albumin. Therefore, the bilirubin-albumin ratio is important in determining the type of activity [10,11]. Traditional phototherapy has negative impacts on the antioxidant defense system in term

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prooxidant and antioxidant activities of rosmarinic acid

PROOXIDANT AND ANTIOXIDANT ACTIVITIES OF ROSMARINIC ACID

In addition, its melanogenic prooxidant activity is characterized as it acts as a substrate of polyphenol oxidase to generate o‐quinones, and its antimelanogenic and, so, antioxidant activity as it carries out the suicide inactivation of polyphenol oxidase. The balance between its pro‐ and antioxidant activities demonstrates that rosmarinic

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is there a balance between oxidative stress and antioxidant

IS THERE A BALANCE BETWEEN OXIDATIVE STRESS AND ANTIOXIDANT

is thought to be primarily bilirubin. Furthermore, physiolog-ical concentration of bilirubin functions as a potent antioxi-dant by reacting with ROS and, subsequently, becomes oxidized (55, 86). Hence, BOM rather than bilirubin per se could be a good marker for evaluating the antioxidant activity of bilirubin under oxidative stress (62).

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welcome to ecronicon

Welcome to ECronicon

Asad SF., et al. “Prooxidant and antioxidant activities of bilirubin and its metabolic precursor biliverdin: A structure-activity study”. Chemico- Biological Interactions 137.1 (2001): 59-74. Beltz EE and Mullins ME. “Radiological Reasoning: Hyperintensity of the Basal Ganglia and Cortex on FLAIR and Diffusion-Weighted Imaging Volume”.

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pro-oxidant - wikipedia

Pro-oxidant - Wikipedia

The relative importance of the antioxidant and pro-oxidant activities of antioxidant vitamins are an area of current research, but vitamin C, for example, appears to have a mostly antioxidant action in the body. However, less data is available for other dietary antioxidants, such as polyphenol antioxidants, zinc, and vitamin E.

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prooxidant-antioxidant balance in iranian veterans exposed to

Prooxidant-antioxidant balance in Iranian veterans exposed to

Prooxidant-antioxidant balance in Iranian veterans exposed to mustard gas and its correlation with biochemical and hematological parameters Daryoush Hamidi Alamdari Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Correspondence [email protected]

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physiological antioxidative network of the bilirubin system

Physiological Antioxidative Network of the Bilirubin System

But it should be reminded that bilirubin possesses both antioxidant and prooxidant properties. Bilirubin shows hormeric dose responses, as illustrated by that it protects red blood cells against oxidative stress at physiologic concentrations, while it is associated with significant cytotoxicity at concentrations of 30 mg/dL or higher ( Mireles

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bilirubin improves the quality and function of hypothermic

Bilirubin Improves the Quality and Function of Hypothermic

RESULTS: Bilirubin could prevent cellular damages during short-term preservation and maintain the cocultured islets viability and function. The protective role of bilirubin is associated with its antioxidative ability, which dramatically increased the activities of antioxidant enzymes (superoxide dismutase and glutathione peroxidase) and

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effect of phototherapy on pro-oxidant/antioxidant balance in

Effect of phototherapy on pro-oxidant/antioxidant balance in

is a unit stimulating the production of oxygen and acting as an antioxidant, especially when combined with albumin. Therefore, the bilirubin-albumin ratio is important in determining the type of activity [10,11]. Traditional phototherapy has negative impacts on the antioxidant defense system in term

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antioxidant activities of bile pigments | antioxidants

Antioxidant Activities of Bile Pigments | Antioxidants

This article reviews the in vitro antioxidant activities of the two bile pigments with emphasis on the different physiological forms of bilirubin and types of oxidants, and discusses these properties in light of the presence and reactivity other nonproteinaceous antioxidants. Antioxid. Redox Signal. 6, 841–849. back.

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role of heme oxygenase and bilirubin in oxidative stress in

Role of Heme Oxygenase and Bilirubin in Oxidative Stress in

Nevertheless, although the antioxidant effect of bilirubin as a scavenger of reactive oxygen species is well documented in vitro (5–8) as well as in animal studies , its role in vivo has not

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antioxidant and prooxidant activity a-tocopherol in low

Antioxidant and prooxidant activity a-tocopherol in low

Abstract a-Tocopherol is a classical lipophilic antioxidant well known as a scavenger of free radicals in a hydrophobic milieu. However, it can develop both anti- and prooxidant activity in isolated low density lipoprotein (LDL). It is un- known how these activities are balanced in vivo in human plasma.

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prooxidant and antioxidant activities of macrophages in metal

Prooxidant and Antioxidant Activities of Macrophages in Metal

These differences may explain the relative inability of RPMI to support oxidation, and hence cell-associated antioxidative processes may override simultaneous cellular prooxidant activities. Several mechanisms could be involved in the inhibition of LDL oxidation. Metal sequestration by macrophages is known to occur.

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is there a balance between oxidative stress and antioxidant

IS THERE A BALANCE BETWEEN OXIDATIVE STRESS AND ANTIOXIDANT

is thought to be primarily bilirubin. Furthermore, physiolog-ical concentration of bilirubin functions as a potent antioxi-dant by reacting with ROS and, subsequently, becomes oxidized (55, 86). Hence, BOM rather than bilirubin per se could be a good marker for evaluating the antioxidant activity of bilirubin under oxidative stress (62).

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