plasticizer effect in film coating tablet formulation

variation of composition of an enteric formulation based on

Variation of composition of an enteric formulation based on

Using a formulation described previously with Kollicoat MAE 30 D as the film-forming agent, the effect of variations in plasticizer type and quantity and talc concentration on the preparation and processing of spray-coating suspensions and the properties of isolated films and film-coated caffeine tablets prepared using them was investigated.

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plasticizers in paint & coatings: uses, types and selection

Plasticizers in Paint & Coatings: Uses, Types and Selection

Plasticizers are additives that increase the plasticity or fluidity of a material. Coating formulations based on physically drying binders such as nitrocellulose, require external plasticizers for optimal film formation. They are used to control the film formation process of coatings based on physically drying film-forming materials.

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plasticizer presentation final - slideshare

Plasticizer Presentation Final - SlideShare

Plasticizer Presentation Final 1. PAS 243 Product formulation Spring 2008 Instructor :- Dr.B.D.Rohera Presented by Deepa Nair 1 Effect of plasticizers in film coating of tablets .

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pharmaceutical applications of plasticized polymers

Pharmaceutical Applications of Plasticized Polymers

2.1 The role of the plasticizer in the film coating The plasticizer plays the major role in the all process of the oral dosage form coating, and significantly influences the quality of the coatings, particularly the release of incorporated drugs. 2.1.1 Film formation facilitated by plasticizer The film-formation mechanism from the coating

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review on polymers used for film coating - asian journal of

Review on polymers used for film coating - Asian Journal of

polymers are also used in developing aqueous film coating formulations like sodium carboxymethylcellulose, polyvinylalcohol, polyvinyl pyrrolidone, sodium Alginate, Polyethylene Glycoletc either alone or in combinations. 2.1.2. PLASTICIZERS: The next most important components of the coating formulation are plasticizers.

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comparing various plasticisers regarding their effect on the

Comparing various plasticisers regarding their effect on the

This is because characteristics such as water up-take of a tablet core during the first 2 hours of the dissolution test as this strongly depends on the hydrophilic-lipophilic character of the coat. This work was intended to compare the impact of 7 hydrophilic and 3 lipophilic plasticisers on the characteristics of a MAE based coating formulations.

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film coating - an overview | sciencedirect topics

Film Coating - an overview | ScienceDirect Topics

Film-coating formulations, depending on the properties of the materials used and the ultimate functionality of the coating required, commonly comprise 5%–35% (w/w) coating solids in the requisite vehicle (with the higher concentration range preferred for aqueous formulations), of which 60%–70% is polymer, 6%–7% is plasticizer, and 15%

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pharmaceutical applications of plasticized polymers

Pharmaceutical Applications of Plasticized Polymers

2.1 The role of the plasticizer in the film coating The plasticizer plays the major role in the all process of the oral dosage form coating, and significantly influences the quality of the coatings, particularly the release of incorporated drugs. 2.1.1 Film formation facilitated by plasticizer The film-formation mechanism from the coating

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effect of plasticizer on release kinetics of diclofenac

Effect of Plasticizer on Release Kinetics of Diclofenac

Aqueous film-coating dispersions generally consist of polymeric colloidal particles, a plasticizer, a pigment, and an anti-adherent agent. Most polymers employed for the film-coating of pellets and tablets are brittle at room temperature and require the use of plasticizers to improve their handling and processing . The most widely used aqueous

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review on polymers used for film coating - asian journal of

Review on polymers used for film coating - Asian Journal of

polymers are also used in developing aqueous film coating formulations like sodium carboxymethylcellulose, polyvinylalcohol, polyvinyl pyrrolidone, sodium Alginate, Polyethylene Glycoletc either alone or in combinations. 2.1.2. PLASTICIZERS: The next most important components of the coating formulation are plasticizers.

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film coatings for taste masking and moisture protection

Film coatings for taste masking and moisture protection

Besides different formulation concepts, film coating is found to be the most effective and commonly used approach for taste masking and moisture protection. Film coating can be achieved through the use of water-soluble, cationic, anionic or neutral insoluble polymers from different chemical structures.

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film coating - an overview | sciencedirect topics

Film Coating - an overview | ScienceDirect Topics

Film-coating formulations, depending on the properties of the materials used and the ultimate functionality of the coating required, commonly comprise 5%–35% (w/w) coating solids in the requisite vehicle (with the higher concentration range preferred for aqueous formulations), of which 60%–70% is polymer, 6%–7% is plasticizer, and 15%

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colorcon® | film coatings for tablets

Colorcon® | Film Coatings for Tablets

Immediate Release – A distinctive product appearance offers many benefits to the producers and marketers of pharmaceutical tablets and nutritional supplements. Film coating is the most economical method of enhancing your product – helping positively impact patient preference, differentiating your product's visual appearance, as well as improving the ability to swallow and masking

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problems and remedies for tablet coating

PROBLEMS AND REMEDIES FOR TABLET COATING

• Decrease the rater of application of coating solution by increasing viscosity of coating solution. Pitting. It is defect whereby pits occur in the surface of a tablet core without any visible disruption of the film coating. Reason: Temperature of the tablet core is greater than the melting point of the materials used in the tablet formulation.

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problems and remedies for tablet coating

Problems and Remedies for Tablet Coating

Remedies. 1. Higher internal stresses in the film than the tensile strength of the film. Adjusting the type and concentration of plasticizer. 2. High molecular weight polymeric blends or polymers. Use lower molecular weight polymeric blends or polymers. 3. Coating and core have different thermal expansion properties.

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[effects of plasticizers and surfactants on the film forming

[Effects of plasticizers and surfactants on the film forming

[Effects of plasticizers and surfactants on the film forming properties of hydroxypropyl methylcellulose for the coating of diclofenac sodium tablets]

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the permeability of enteric coatings and the dissolution

The permeability of enteric coatings and the dissolution

Suitable formulations of each polymer were used to enteric coat 325 mg aspirin tablets, which were subsequently subjected to both the Disintegration Test for Enteric Coated Tablets B.P. and a dissolution procedure to monitor the release of drug in simulated gastric juice and simulated intestinal fluid.

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non-traditional application of drug and excipient by pinak

NON-TRADITIONAL APPLICATION OF DRUG AND EXCIPIENT by PINAK

During formulation development, there are cases when, serendipitously, drug or excipients play a different role than intended one or a dual role. One of the examples of a non-traditional role is of a drug acting as a plasticizer. Plasticization tendency of APIs on polymers can be advantageous for hot melt extrusion, and film coating application.

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coating of pharmaceutical dosage forms - sciencedirect

Coating of pharmaceutical dosage forms - ScienceDirect

Film-coating formulations, depending on the properties of the materials used and the ultimate functionality of the coating required, commonly comprise 5%–35% (w/w) coating solids in the requisite vehicle (with the higher concentration range preferred for aqueous formulations), of which 60%–70% is polymer, 6%–7% is plasticizer, and 15%

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colorcon® | film coatings for tablets

Colorcon® | Film Coatings for Tablets

Immediate Release – A distinctive product appearance offers many benefits to the producers and marketers of pharmaceutical tablets and nutritional supplements. Film coating is the most economical method of enhancing your product – helping positively impact patient preference, differentiating your product's visual appearance, as well as improving the ability to swallow and masking

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film cracking - film coating troubleshooting

Film Cracking - Film Coating Troubleshooting

The correct formulation of the film coating can have a significant effect on film adhesion and thus the ability to minimize problems, such as logo bridging and other adhesion-related problems. The positive impact of careful film coating selection on maximizing coating adhesion and minimizing problems such as logo bridging is illustrated below.

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problems and remedies for tablet coating

Problems and Remedies for Tablet Coating

Remedies. 1. Higher internal stresses in the film than the tensile strength of the film. Adjusting the type and concentration of plasticizer. 2. High molecular weight polymeric blends or polymers. Use lower molecular weight polymeric blends or polymers. 3. Coating and core have different thermal expansion properties.

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a quality by design approach for coating process parameter

A Quality by Design Approach for Coating Process Parameter

traditional film coating methods. The process of film coating involves consistently depositing and drying a uniform coating formulation onto the surface of a substrate so as to form a uniform film. Thus, for a good tablet coating, control of process parameters is very important. A poorly developed film coating process

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