metabolism of the plasticizer and phthalate substitute

metabolism of the plasticizer and phthalate substitute

Metabolism of the plasticizer and phthalate substitute

Hexamoll(®) DINCH(®) (diisononyl-cyclohexane-1,2-dicarboxylate) is a new high-molecular-weight plasticizer and a phthalate substitute. In this study, the metabolism of DINCH(®) was investigated by oral dosage of three male volunteers with approximately 50 mg Hexamoll(®) DINCH(®) (resulting in indivi …

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metabolism of the plasticizer and phthalate substitute

Metabolism of the plasticizer and phthalate substitute

Hexamoll® DINCH® (diisononyl-cyclohexane-1,2-dicarboxylate) is a new high-molecular-weight plasticizer and a phthalate substitute. In this study, the metabolism of DINCH® was investigated by oral dosage of three male volunteers with approximately 50 mg Hexamoll® DINCH® (resulting in individual doses between 0.552 and 0.606 mg/kg body weight).

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(pdf) metabolism of the plasticizer and phthalate substitute

(PDF) Metabolism of the plasticizer and phthalate substitute

Hexamoll® DINCH® (diisononyl-cyclohexane-1,2-dicarboxylate) is a new high-molecular-weight plasticizer and a phthalate substitute. In this study, the metabolism of DINCH® was investigated by

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metabolism of the plasticizer and phthalate substitute

Metabolism of the plasticizer and phthalate substitute

Request PDF | On Jan 1, 2013, Koch Hm and others published Metabolism of the plasticizer and phthalate substitute diisononyl-cyclohexane-1,2-dicarboxylate (DINCH(R)) in humans after single oral

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determination of human urinary metabolites of the plasticizer

Determination of human urinary metabolites of the plasticizer

Metabolism of the plasticizer and phthalate substitute diisononyl-cyclohexane-1,2-dicarboxylate (DINCH(®)) in humans after single oral doses Arch. Toxicol. , 87 ( 2013 ) , pp. 799 - 806 , 10.1007/s00204-012-0990-4

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(pdf) metabolism of the phthalate substitute di(2-ethylhexyl

(PDF) Metabolism of the phthalate substitute Di(2-ethylhexyl

DINCH (cyclohexane-1,2-dicarboxylic acid-diisononyl ester) is a phthalate plasticizer substitute introduced into the market in 2002. It is increasingly used especially in the production of toys

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effect of the plasticizer di(2-ethylhexyl) adipate

Effect of the plasticizer di(2-ethylhexyl) adipate

DOA (di[2-ethylhexyl] adipate, dioctyladipate), a plasticizer used in the manufacture of polyvinyl-chloride plastic products, has been considered as a suitable substitute for di(2-ethylhexyl)phthalate (DEHP) in some applications. In the present studies, hepatic lipid metabolism was examined in liver …

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[toxicity effects of phthalate substitute plasticizers used

[Toxicity effects of phthalate substitute plasticizers used

Phthalate esters are widely used as plasticizers in polyvinyl chloride products. Because of human health concerns, regulatory authorities in Japan, US, Europe and other countries control the use of di(2-ethylhexyl) phthalate, diisononyl phthalate, di-n-butyl phthalate, butylbenzyl phthalate, diisode …

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determination of human urinary metabolites of the plasticizer

Determination of human urinary metabolites of the plasticizer

Metabolism of the plasticizer and phthalate substitute diisononyl-cyclohexane-1,2-dicarboxylate (DINCH(®)) in humans after single oral doses Arch. Toxicol. , 87 ( 2013 ) , pp. 799 - 806 , 10.1007/s00204-012-0990-4

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(pdf) metabolism of the phthalate substitute di(2-ethylhexyl

(PDF) Metabolism of the phthalate substitute Di(2-ethylhexyl

DINCH (cyclohexane-1,2-dicarboxylic acid-diisononyl ester) is a phthalate plasticizer substitute introduced into the market in 2002. It is increasingly used especially in the production of toys

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[toxicity effects of phthalate substitute plasticizers used

[Toxicity effects of phthalate substitute plasticizers used

Phthalate esters are widely used as plasticizers in polyvinyl chloride products. Because of human health concerns, regulatory authorities in Japan, US, Europe and other countries control the use of di(2-ethylhexyl) phthalate, diisononyl phthalate, di-n-butyl phthalate, butylbenzyl phthalate, diisode …

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phthalate risks and alternatives | center for advanced life

Phthalate Risks and Alternatives | Center for Advanced Life

Phthalate Risks and Alternatives. Introduction. Plasticizers are substances that are added to a material to increase its plasticity, namely, its flexibility and durability. Phthalates are the most commonly used type of plasticizers and are popular due to their relatively low cost, low volatility, and ability to create very elastic materials.

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additional oxidized and alkyl chain breakdown metabolites of

Additional oxidized and alkyl chain breakdown metabolites of

Hexamoll ® DINCH ® (diisononyl-cyclohexane-1,2-dicarboxylate) is a new high molecular weight plasticizer and a non-aromatic phthalate substitute. In this follow-up study, we further investigated the extensive oxidative metabolism of Hexamoll ® DINCH ® after oral dosage of 50 mg to three male volunteers (0.552–0.606 mg/kg body weight).

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metabolism and urinary excretion kinetics of di(2-ethylhexyl

Metabolism and urinary excretion kinetics of di(2-ethylhexyl

Di(2-ethylhexyl) terephthalate (DEHTP) is used as a substitute for di(2-ethylhexyl) phthalate (DEHP), an ortho-phthalate-based plasticizer that is classified and labeled due to its toxicity to reproduction. In this study the metabolism and urinary excretion kinetics of DEHTP were investigated by single oral dosage of 50 mg DEHTP to three male volunteers (resulting in individual dosages between

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acetyl tributyl citrate, the most widely used phthalate

Acetyl tributyl citrate, the most widely used phthalate

Acetyl tributyl citrate, the most widely used phthalate substitute plasticizer, induces cytochrome P450 3A through steroid and xenobiotic receptor Akira Takeshita, Junko Igarashi-migitaka, Kazusa Nishiyama, Hideyo Takahashi , Yasuhiro Takeuchi, Noriyuki Koibuchi

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substitute for phthalate-based plasticizer in indonesia - new

substitute for phthalate-based plasticizer in indonesia - New

factory price of dioctyl phthalate dop oil for pvc buy dop; substitute for phthalate-based plasticizer in indonesia; liquor gets involved in the scandal of plasticizer; oxo alcohols plasticizers 2-ph evonik performance in philippines; plasticizer on wikinow news videos facts in sri lanka; doa general plasticizer-products- shanghai kunrui chemical

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toxicity and metabolism of monoethylhexyl phthalate and

Toxicity and metabolism of monoethylhexyl phthalate and

Toxicity and metabolism of monoethylhexyl phthalate and diethylhexyl phthalate: a survey of recent literature. Thomas JA, Northup SJ. The literature dealing with monoethylhexyl phthalate (MEHP), the principal metabolite of di (2-ethylhexyl) phthalate (DEHP), a widely used plasticizer, is discussed.

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time trend of exposure to the phthalate plasticizer

Time trend of exposure to the phthalate plasticizer

1. Introduction. Cyclohexane-1,2-dicarboxylic acid-diisononyl ester (DINCH, Hexamoll® DINCH, ELATUR® CH), hereinafter referred to as DINCH, is a substitute for endocrine disrupting and/or regulated high molecular weight phthalate plasticizers (e. g. DEHP: di-(2-ethylhexyl) phthalate; DiNP: di-isononyl phthalate) in the production of plastics, particularly in sensitive applications such as

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phthalates: metabolism and exposure

Phthalates: metabolism and exposure

In human metabolism studies we found that after oral application of di(2-ethyl-hexyl) phthalate (DEHP), diisononyl phthalate (DiNP) and di(2-propylheptyl) phthalate (DPHP), at least 74, 44 and 34%, respectively, are excreted via urine. In contrast to the short chain phthalates, their oxidized products, not the simple

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toxic potential of the plasticizer di(2-ethylhexyl) phthalate

Toxic potential of the plasticizer Di(2-ethylhexyl) phthalate

Toxic potential of the plasticizer Di(2-ethylhexyl) phthalate in the context of its disposition and metabolism in primates and man. Peck CC, Albro PW. Although human toxicity from exposure to the plasticizer di(2-ethylhexyl) phthalate (DEHP) is unknown, reports of animal toxicity from DEHP have stimulated extensive toxicological studies.

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phthalate metabolites: characterization, toxicities, global

Phthalate metabolites: Characterization, toxicities, global

Phthalates are plasticizers in various products and regarded as endocrine disruptors due to their anti-androgen effects. Environmental occurrence and toxicities of parent phthalates have been widely reported, while the current state of knowledge on their metabolites is rarely summarized.

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acetyl tributyl citrate, the most widely used phthalate

Acetyl tributyl citrate, the most widely used phthalate

Acetyl tributyl citrate, the most widely used phthalate substitute plasticizer, induces cytochrome P450 3A through steroid and xenobiotic receptor Akira Takeshita, Junko Igarashi-migitaka, Kazusa Nishiyama, Hideyo Takahashi , Yasuhiro Takeuchi, Noriyuki Koibuchi

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acetyl tributyl citrate, the most widely used phthalate

Acetyl Tributyl Citrate, the Most Widely Used Phthalate

Akira Takeshita, Junko Igarashi-Migitaka, Kazusa Nishiyama, Hideyo Takahashi, Yasuhiro Takeuchi, Noriyuki Koibuchi, Acetyl Tributyl Citrate, the Most Widely Used Phthalate Substitute Plasticizer, Induces Cytochrome P450 3A through Steroid and Xenobiotic Receptor, Toxicological Sciences, Volume 123, Issue 2, October 2011, Pages 460–470, https

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study links phthalate exposure and thyroid function in humans

Study links phthalate exposure and thyroid function in humans

The study found an association between plasticizer metabolites and biomarker levels which indicates that exposure to di-ethyl-hexyl phthalate (DEHP, CAS 117-81-7) metabolites in particular, but also exposure to di-iso-nonyl phthalate (DINP, CAS 28553-12-0), dibutyl phthalate (DBO; CAS 84-72-2), butyl-benzyl phthalate (BBzP; CAS 85-68-7), and

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