effects of dibutyl phthalate in male rabbits following

effects of dibutyl phthalate in male rabbits following in

Effects of dibutyl phthalate in male rabbits following in

We evaluated sequelae in male rabbits following exposure to dibutyl phthalate (DBP) at a dose level known to adversely affect testicular function in rodents without causing systemic toxicity. Because rabbits have a relatively long phase of reproductive development simulating better than rodents the …

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effects of dibutyl phthalate in male rabbits following in

Effects of Dibutyl Phthalate in Male Rabbits following in

Effects of Dibutyl Phthalate in Male Rabbits following in Utero, Adolescent, or Postpubertal Exposure Ty T. Higuchi,* Jennifer S. Palmer,* L. Earl Gray, Jr.,† and D. N. Rao Veeramachaneni*,1 *Animal Reproduction and Biotechnology Laboratory, Colorado State University, Fort Collins, Colorado 80523-1683; and †National Health

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effects of dibutyl phthalate in male rabbits following in

EFFECTS OF DIBUTYL PHTHALATE IN MALE RABBITS FOLLOWING IN

Effects of dibutyl phthalate in male rabbits following in utero, adolescent, or post-pubertal exposureTy T. Higuchi1, Jennifer S. Palmer1, L. Earl Gray Jr2., and D. N. Rao Veeramachaneni11Animal Reproduction and Biotechnology Laboratory, Colorado State University, FortCollins, CO; and 2National Health and Environmental Effects Research Laboratory,USEPA, Research Triangle Park, NC.AbstractWe

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effects of dibutyl phthalate in male rabbits following in

Effects of Dibutyl Phthalate in Male Rabbits following in

Abstract. We evaluated sequelae in male rabbits following exposure to dibutyl phthalate (DBP) at a dose level known to adversely affect testicular function in rodents without causing systemic toxicity.

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effects of dibutyl phthalate in male rabbits following in

Effects of Dibutyl Phthalate in Male Rabbits following in

Request PDF | On May 1, 2003, Ty T Higuchi and others published Effects of Dibutyl Phthalate in Male Rabbits following in Utero, Adolescent, or Postpubertal Exposure | Find, read and cite all the

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citeseerx — effects of dibutyl phthalate in male rabbits

CiteSeerX — Effects of dibutyl phthalate in male rabbits

CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): We evaluated sequelae in male rabbits following exposure to dibutyl phthalate (DBP) at a dose level known to adversely affect testicular function in rodents without causing systemic toxicity.

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a dose response study to assess effects after dietary

A Dose Response Study to Assess Effects After Dietary

Male rat sexual development was evaluated after dietary administration of 0, 760, 3800, 11,400 ppm diisononyl phthalate (DiNP) and 7600 ppm dibutyl phthalate (DBP) from gestation day (GD) 12 to postnatal day (PND) 14. Maternal weight was reduced on GD 20, PND 2 and 14 at 11,400 ppm DiNP. Pup weight …

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dibutyl phthalate-induced neurotoxicity in the brain of

Dibutyl phthalate-induced neurotoxicity in the brain of

Effects of dibutyl phthalate in male rabbits following in utero, adolescent, or postpubertal exposure Toxicol Sci , 72 ( 2003 ) , pp. 301 - 313 View Record in Scopus Google Scholar

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effect of dibutyl phthalate on sperm quality and liver injury

Effect of Dibutyl Phthalate on Sperm Quality and Liver Injury

Abstract:The modifying effects of liver injury and semen quality after DBP exposure were studied using male adult rabbits. Twenty for male animals, aged 6 months at the commencement, were divided into 4 groups of 6 rabbits each. Rabbits in DBP-exposed groups were given DBP at a dose of 250, 500 and 750 mg/kg/day for 4 weeks.

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cumulative effects of dibutyl phthalate and diethylhexyl

Cumulative Effects of Dibutyl Phthalate and Diethylhexyl

Exposure to plasticizers di(n-butyl) phthalate (DBP) and diethylhexyl phthalate (DEHP) during sexual differentiation causes male reproductive tract malformations in rats and rabbits. In the fetal male rat, these two phthalate esters decrease testosterone (T) production and insulin-like peptide 3 (insl3) gene expression, a hormone critical for

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dibutyl phthalate-induced neurotoxicity in the brain of

Dibutyl phthalate-induced neurotoxicity in the brain of

Effects of dibutyl phthalate in male rabbits following in utero, adolescent, or postpubertal exposure Toxicol Sci , 72 ( 2003 ) , pp. 301 - 313 View Record in Scopus Google Scholar

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adverse effects of environmental antiandrogens and androgens

Adverse effects of environmental antiandrogens and androgens

Di-n-butyl phthalate also disrupts reproductive function in the rabbit. In rabbits exposed to 400 mg DBP/kg/day in utero (GD 15–29), male offspring exhibit reduced numbers of ejaculated sperm (down 43%), testis weights (at 12 weeks, down 23%) and accessory sex gland weights (at 12 and 25 weeks, down 36% and 27% respectively) ( Higuchi et al

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d. n. rao veeramachaneni, bvsc, mscvet, phd

D. N. Rao Veeramachaneni, BVSc, MScVet, PhD

Effects of dibutyl phthalate in male rabbits following in utero, adolescent, or post-pubertal exposure. Toxicol Sci 72:301-313. Lange IG, Daxenberger A, Meyer HHD, Rajpert-De Meyts E, Skakkebaek NE, Veeramachaneni DNR. 2002.

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dibutyl phthalate | c16h22o4 - pubchem

Dibutyl phthalate | C16H22O4 - PubChem

Dibutyl phthalate is a phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.

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the dirty dozen: dibutyl phthalate - david suzuki foundation

The Dirty Dozen: Dibutyl Phthalate - David Suzuki Foundation

iv Barlow NJ, McIntyre BS, Foster PM. “Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalate.” Toxicol Pathol.32, 1 (Jan-Feb 2004):79-90. v BKH. Towards the establishment of a priority list of substances for further evaluation of their role in endocrine disruption.

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(pdf) anomalie congénitale peu fréquente chez le lapin

(PDF) Anomalie congénitale peu fréquente chez le lapin

Effects of dibutyl . phthalate in male rabbits following in utero, adolescent, o r postpubertal exposure. Toxicol . Sci. 2003;72(2):301-13. Meyer J. Geneti sche Defekte und züchterische .

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effect of dibutyl phthalate on sperm quality and liver injury

Effect of Dibutyl Phthalate on Sperm Quality and Liver Injury

Abstract:The modifying effects of liver injury and semen quality after DBP exposure were studied using male adult rabbits. Twenty for male animals, aged 6 months at the commencement, were divided into 4 groups of 6 rabbits each. Rabbits in DBP-exposed groups were given DBP at a dose of 250, 500 and 750 mg/kg/day for 4 weeks.

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cumulative effects of dibutyl phthalate and diethylhexyl

Cumulative Effects of Dibutyl Phthalate and Diethylhexyl

Exposure to plasticizers di(n-butyl) phthalate (DBP) and diethylhexyl phthalate (DEHP) during sexual differentiation causes male reproductive tract malformations in rats and rabbits. In the fetal male rat, these two phthalate esters decrease testosterone (T) production and insulin-like peptide 3 (insl3) gene expression, a hormone critical for

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mode of action and human relevance evaluation of dibutyl

Mode of action and human relevance evaluation of Dibutyl

DBP-induced Leydig cell effects are conserved in different mammalian species: (rats, rabbits, mice, gerbils, and guinea pigs, non-human primates [in-vivo and xenografts]). DBP-induced effects in the seminiferous cord (SC & GC) are also conserved among most mammalian models (rats, mice, and non-human primate [xenograft]).

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[effects of dibutyl phthalate on sertoli cells of rat testis].

[Effects of dibutyl phthalate on sertoli cells of rat testis].

OBJECTIVE: The present study was performed to examine functional and structural impairment of rat sertoli cells following dibutyl phthalate (DBP) exposure. METHODS: The 6-week-old healthy male Sprague Dawley rats were randomly divided into 4 groups with 16 animals in each group.

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antiandrogenic effects of dibutyl phthalate and its

Antiandrogenic effects of dibutyl phthalate and its

ABSTRACT Developmental toxicity following administration of dibutyl phthalate (DBF) and its major metabolite, monobutyl phthalate (MBuP), by gavage was determined in Wistar rats. DBF on days 0–8 of pregnancy induced an increase in the incidence of preimplantation loss at 1250 mg/kg and higher and postimplantation loss at 750 mg/kg and higher.

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medirabbit

MediRabbit

Effects of dibutyl phthalate in male rabbits following in utero, adolescent, or postpubertal exposure. Toxicol Sci. 2003 ;72 (2):301-13. Meyer J. Genetische Defekte und züchterische Auslese.

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right to know hazardous substance fact sheet

Right to Know Hazardous Substance Fact Sheet

effects described below. Health Hazard Information Acute Health Effects The following acute (short-term) health effects may occur immediately or shortly after exposure to Di-n-Butyl Phthalate: f Contact can irritate the skin and eyes. f Inhaling Di-n-Butyl Phthalate can irritate the nose and throat. f Exposure to Di-n-Butyl Phthalate can cause

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neurotoxicity of dibutyl phthalate in brain development

Neurotoxicity of dibutyl phthalate in brain development

Dibutyl-phthalate (DBP) is a ubiquitous environmental contaminant. However, its neurotoxic effects on neonatal, immature or mature brains remain unclear. Here, we aimed to investigate the neurotoxicity of perinatal exposure of DBP on rodent offspring animals.

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